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Pigmented villonodular synovitis
Pigmented villonodular synovitis is a rare disease affecting the joints, most often the knee though also the ankle and elbow. It is characterised by the tumefaction of the membrane producing the synovial fluid and brown nodules composed of iron pigments capable of penetrating the bone. This disease, assumed to be of cancerous origin of the family of soft tissue cancers, affecting young adults in particular, evolves slowly and generally does not spread. However it is complicated to treat and relapses are frequent.