A long awaited facility
The Lyon Cancer Research Center (CRCL) and the Léon Bérard Center (CLB) joined together with the Synergie Lyon Cancer Foundation to set up the Drug Discovery and Development Center (C3D), to satisfy the long long-expressed needs of the network of 150 internationally acknowledged researchers in Lyon.
This pharmaceutical research center dedicated to cancerology is located on the CLB site and completes the technological facilities at the interface between fundamental and clinical research already funded and set up by the Synergie Lyon Cancer Foundation, such as the bioinformatics center and the tumour model laboratory (LMT).
Pooling resources at the service of innovation
The goal of the Drug Discovery and Development Center is to give fundamental research teams that have discovered a gene, protein or a signaling pathway involved in the development of cancer, tools for defining molecules of interest known as “candidate drugs” acting against this target. The availability of this center at the core of research and care in Lyon allows scientists to:
- accelerate the transfer of the results obtained by fundamental research to applied research,
- facilitate the implementation of clinical studies and performing further studies of drugs liable to cover as yet unsatisfied medical needs.
The Drug Discovery and Development Center has been designed to better satisfy the expectations of industrial companies regarding academic research in the commercial development of molecules: provide validated data and proof of concepts in a state as finalized as possible for a potential drug,
Sylvie Négrier, General Manager of the CLB and instigator of the Drug Discovery and Development Center.
An environment of expertise in cancerology
Under the management of Stéphane Giraud, the Drug Discovery and Development Center offers researchers a high level scientific and medical environment as well as innovative infrastructures. It has its own technological installations and the multidisciplinary competences (biology, medicinal chemistry, non-clinical development) needed to drive a pharmaceutical research project.
Endowed with all the equipment indispensable for biochemistry, molecular biology, the manipulation of all types of cell and a collection of tens of thousands of molecules, the center has recently acquired a robot that is used to test the effect of hundreds and even thousands of compounds in a single day. The center’s equipment is completed by two mass spectrometers dedicated to the detection and analysis of molecules in complex media such as blood plasma.